OmniISR: A Unified Framework for Centralized and Federated Learning via Intermediate Supervision and Regularization

The global deployment of edge intelligence operates across heterogeneous legal frameworks. While some regions permit centralized learning (CL) via cloud data aggregation, others enforce strict data localization, necessitating federated learning (FL). This operational dichotomy introduces two incompatible optimization regimes (i.e., unbiased global gradients yet coupled with internal covariate shift in CL versus biased, drift-prone local updates in FL), resulting in that any naive integration of the two lacks rigorous theoretical guarantees. To fill this gap, we propose OmniISR, a unified framework that fuses pure CL, pure FL, and hybrid CL-FL training modes via equipping intermediate supervision and regularization (ISR) signals at multiple hidden layers. Specifically, we propose (i) to use mutual-information (MI) as intermediate supervision to align shifting internal covariate in CL and client-drifting representations in FL, and (ii) to adopt negative-entropy (NE) as intermediate regularizer to penalize overconfident prediction, preserve representational uncertainty, and avoid device-specific collapse. On the theory side, we derive (i) a unified, ISR-agnostic, and non-asymptotic O(1/sqrt(T)) convergence bound that shows the introduced ISR does not violate standard SGD convergence, (ii) a federated drift-bound that quantifies the ISR-reduced client drift, (iii) a gradient-alignment guarantee that ensures non-conflicting CL and FL updates under mild bias, and (iv) an explicit escape-time bound that indicates that CL-FL hybrid mixing enlarges effective stochasticity and accelerates escape from strict saddles. Extensive experiments demonstrate that OmniISR consistently improves model performance in both centralized and federated paradigms, reduces the CL-FL gap by 22.60%, and yields 37/48 paired metric wins across multiple FL algorithms.

Decomposing the Generalization Gap in PROTAC Activity Prediction: Variance Attribution and the Inter-Laboratory Ceiling

Machine-learning predictors of biochemical activity often exhibit large random-split-to-leave-one-target-out generalisation gaps that have been documented but not decomposed. We frame this as an evaluation-science question and use targeted protein degradation as the empirical test bed. PROTACs (proteolysis-targeting chimeras) are heterobifunctional small molecules that induce targeted protein degradation, with more than forty candidates currently in clinical trials; published predictors report AUROC of 0.85 to 0.91 under random-split cross-validation, while the leave-one-target-out (LOTO) protocol of Ribes et al. reduces performance to approximately 0.67. Random splits reward within-target interpolation, whereas LOTO measures the novel-target prediction that de-novo design depends on. We decompose this gap and identify inter-laboratory measurement variance as the dominant component, anchored by a within-target cross-laboratory cascade bounding the inter-laboratory contribution at 0.124 AUROC, well above the 0.05 contribution from binarisation-threshold choice. Across eight published architectures and ESM-2 protein language models up to 3B parameters, LOTO AUROC plateaus near 0.67, with a comparable plateau under SMILES-level deduplication; a 21-dimensional 2000-trial hyperparameter optimisation cannot break this ceiling, and the rank-1 single-seed configuration regresses by 0.161 AUROC under multi-seed validation, matching a closed-form selection-bias prediction (Bailey and Lopez de Prado, 2014). Few-shot k=5 stratified per-target retraining combined with ADMET features lifts 65-target LOTO AUROC from 0.668 to 0.7050, and post-hoc Platt scaling recovers raw output to within the 0.05 well-calibrated threshold. We release PROTAC-Bench (10,748 measurements, 173 targets, 65 LOTO folds), the variance-decomposition framework, the per-target calibration protocol, and the evaluation code.

CurvZO: Adaptive Curvature-Guided Sparse Zeroth-Order Optimization for Efficient LLM Fine-Tuning

Fine-tuning large language models (LLMs) with backpropagation achieves high performance but incurs substantial memory overhead, limiting scalability on resource-constrained hardware. Zeroth-order (ZO) optimization provides a memory-efficient alternative by relying solely on forward passes, yet it typically suffers from slow or unstable convergence due to high-variance gradient estimates. Sparse ZO updates partially address this issue by perturbing only a subset of parameters, but their effectiveness hinges on selecting informative parameters, which is challenging in ZO optimization because each query yields only scalar feedback. We propose \textbf{Adaptive Curvature-Guided Sparse Zeroth-Order Optimization (CurvZO)}, which tracks curvature signals online from scalar ZO feedback and leverages these signals to construct a parameter-wise sampling distribution for selecting coordinates at each update, reducing the variance of the sparse ZO gradient estimator. Moreover, CurvZO dynamically adapts the perturbation budget to the evolving curvature signal distribution, yielding sparse ZO updates that remain both focused and sufficiently exploratory. Extensive experiments on OPT and Llama across diverse NLP tasks show that CurvZO consistently improves fine-tuning performance and reduces training time over ZO baselines. It improves accuracy by up to 4.4 points and achieves up to a $2\times$ speedup, while preserving memory efficiency.

Listening with the Eyes: Benchmarking Egocentric Co-Speech Grounding across Space and Time

In situated collaboration, speakers often use intentionally underspecified deictic commands (e.g., ``pass me \textit{that}''), whose referent becomes identifiable only by aligning speech with a brief co-speech pointing \emph{stroke}. However, many embodied benchmarks admit language-only shortcuts, allowing MLLMs to perform well without learning the \emph{audio--visual alignment} required by deictic interaction. To bridge this gap, we introduce \textbf{Egocentric Co-Speech Grounding (EcoG)}, where grounding is executable only if an agent jointly predicts \textit{What}, \textit{Where}, and \textit{When}. To operationalize this, we present \textbf{EcoG-Bench}, an evaluation-only bilingual (EN/ZH) diagnostic benchmark of \textbf{811} egocentric clips with dense spatial annotations and millisecond-level stroke supervision. It is organized under a \textbf{Progressive Cognitive Evaluation} protocol. Benchmarking state-of-the-art MLLMs reveals a severe executability gap: while human subjects achieve near-ceiling performance on EcoG-Bench (\textbf{96.9\%} strict Eco-Accuracy), the best native video-audio setting remains low (Gemini-3-Pro: \textbf{17.0\%}). Moreover, in a diagnostic ablation, replacing the native video--audio interface with timestamped frame samples and externally verified ASR (with word-level timing) substantially improves the same model (\textbf{17.0\%}$\to$\textbf{42.9\%}). Overall, EcoG-Bench provides a strict, executable testbed for event-level speech--gesture binding, and suggests that multimodal interfaces may bottleneck the observability of temporal alignment cues, independently of model reasoning.

FLoRG: Federated Fine-tuning with Low-rank Gram Matrices and Procrustes Alignment

Parameter-efficient fine-tuning techniques such as low-rank adaptation (LoRA) enable large language models (LLMs) to adapt to downstream tasks efficiently. Federated learning (FL) further facilitates this process by enabling collaborative fine-tuning across distributed clients without sharing private data. However, the use of two separate low-rank matrices in LoRA for federated fine-tuning introduces two types of challenges. The first challenge arises from the error induced by separately aggregating those two low-rank matrices. The second challenge occurs even when the product of two low-rank matrices is aggregated. The server needs to recover factors via matrix decomposition, which is non-unique and can introduce decomposition drift. To tackle the aforementioned challenges, we propose FLoRG, a federated fine-tuning framework which employs a single low-rank matrix for fine-tuning and aggregates its Gram matrix (i.e., the matrix of inner products of its column vectors), eliminating the aggregation error while also reducing the communication overhead. FLoRG minimizes the decomposition drift by introducing a Procrustes alignment approach which aligns the decomposed matrix between consecutive fine-tuning rounds for consistent updates. We theoretically analyze the convergence of FLoRG and prove that adopting the Procrustes alignment results in a tighter convergence bound. Experimental results across multiple LLM fine-tuning benchmarks demonstrate that FLoRG outperforms five state-of-the-art baseline schemes in the downstream task accuracy and can reduce the communication overhead by up to 2041$\times$.

Investigating the Impact of Histopathological Foundation Models on Regressive Prediction of Homologous Recombination Deficiency

Foundation models pretrained on large-scale histopathology data have found great success in various fields of computational pathology, but their impact on regressive biomarker prediction remains underexplored. In this work, we systematically evaluate histopathological foundation models for regression-based tasks, demonstrated through the prediction of homologous recombination deficiency (HRD) score - a critical biomarker for personalized cancer treatment. Within multiple instance learning frameworks, we extract patch-level features from whole slide images (WSI) using five state-of-the-art foundation models, and evaluate their impact compared to contrastive learning-based features. Models are trained to predict continuous HRD scores based on these extracted features across breast, endometrial, and lung cancer cohorts from two public medical data collections. Extensive experiments demonstrate that models trained on foundation model features consistently outperform the baseline in terms of predictive accuracy and generalization capabilities while exhibiting systematic differences among the foundation models. Additionally, we propose a distribution-based upsampling strategy to mitigate target imbalance in these datasets, significantly improving the recall and balanced accuracy for underrepresented but clinically important patient populations. Furthermore, we investigate the impact of different sampling strategies and instance bagsizes by ablation studies. Our results highlight the benefits of large-scale histopathological pretraining for more precise and transferable regressive biomarker prediction, showcasing its potential to advance AI-driven precision oncology.

Decoupled Split Learning via Auxiliary Loss

Split learning is a distributed training paradigm where a neural network is partitioned between clients and a server, which allows data to remain at the client while only intermediate activations are shared. Traditional split learning relies on end-to-end backpropagation across the client-server split point. This incurs a large communication overhead (i.e., forward activations and backward gradients need to be exchanged every iteration) and significant memory use (for storing activations and gradients). In this paper, we develop a beyond-backpropagation training method for split learning. In this approach, the client and server train their model partitions semi-independently, using local loss signals instead of propagated gradients. In particular, the client's network is augmented with a small auxiliary classifier at the split point to provide a local error signal, while the server trains on the client's transmitted activations using the true loss function. This decoupling removes the need to send backward gradients, which cuts communication costs roughly in half and also reduces memory overhead (as each side only stores local activations for its own backward pass). We evaluate our approach on CIFAR-10 and CIFAR-100. Our experiments show two key results. First, the proposed approach achieves performance on par with standard split learning that uses backpropagation. Second, it significantly reduces communication (of transmitting activations/gradient) by 50% and peak memory usage by up to 58%.

GeM-VG: Towards Generalized Multi-image Visual Grounding with Multimodal Large Language Models

Multimodal Large Language Models (MLLMs) have demonstrated impressive progress in single-image grounding and general multi-image understanding. Recently, some methods begin to address multi-image grounding. However, they are constrained by single-target localization and limited types of practical tasks, due to the lack of unified modeling for generalized grounding tasks. Therefore, we propose GeM-VG, an MLLM capable of Generalized Multi-image Visual Grounding. To support this, we systematically categorize and organize existing multi-image grounding tasks according to their reliance of cross-image cues and reasoning, and introduce the MG-Data-240K dataset, addressing the limitations of existing datasets regarding target quantity and image relation. To tackle the challenges of robustly handling diverse multi-image grounding tasks, we further propose a hybrid reinforcement finetuning strategy that integrates chain-of-thought (CoT) reasoning and direct answering, considering their complementary strengths. This strategy adopts an R1-like algorithm guided by a carefully designed rule-based reward, effectively enhancing the model's overall perception and reasoning capabilities. Extensive experiments demonstrate the superior generalized grounding capabilities of our model. For multi-image grounding, it outperforms the previous leading MLLMs by 2.0% and 9.7% on MIG-Bench and MC-Bench, respectively. In single-image grounding, it achieves a 9.1% improvement over the base model on ODINW. Furthermore, our model retains strong capabilities in general multi-image understanding.

Improving Generalization in LLM Structured Pruning via Function-Aware Neuron Grouping

Large Language Models (LLMs) demonstrate impressive performance across natural language tasks but incur substantial computational and storage costs due to their scale. Post-training structured pruning offers an efficient solution. However, when few-shot calibration sets fail to adequately reflect the pretraining data distribution, existing methods exhibit limited generalization to downstream tasks. To address this issue, we propose Function-Aware Neuron Grouping (FANG), a post-training pruning framework that alleviates calibration bias by identifying and preserving neurons critical to specific function. FANG groups neurons with similar function based on the type of semantic context they process and prunes each group independently. During importance estimation within each group, tokens that strongly correlate with the functional role of the neuron group are given higher weighting. Additionally, FANG also preserves neurons that contribute across multiple context types. To achieve a better trade-off between sparsity and performance, it allocates sparsity to each block adaptively based on its functional complexity. Experiments show that FANG improves downstream accuracy while preserving language modeling performance. It achieves the state-of-the-art (SOTA) results when combined with FLAP and OBC, two representative pruning methods. Specifically, FANG outperforms FLAP and OBC by 1.5%--8.5% in average accuracy under 30% and 40% sparsity.

ESearch-R1: Learning Cost-Aware MLLM Agents for Interactive Embodied Search via Reinforcement Learning

Multimodal Large Language Models (MLLMs) have empowered embodied agents with remarkable capabilities in planning and reasoning. However, when facing ambiguous natural language instructions (e.g., "fetch the tool" in a cluttered room), current agents often fail to balance the high cost of physical exploration against the cognitive cost of human interaction. They typically treat disambiguation as a passive perception problem, lacking the strategic reasoning to minimize total task execution costs. To bridge this gap, we propose ESearch-R1, a cost-aware embodied reasoning framework that unifies interactive dialogue (Ask), episodic memory retrieval (GetMemory), and physical navigation (Navigate) into a single decision process. We introduce HC-GRPO (Heterogeneous Cost-Aware Group Relative Policy Optimization). Unlike traditional PPO which relies on a separate value critic, HC-GRPO optimizes the MLLM by sampling groups of reasoning trajectories and reinforcing those that achieve the optimal trade-off between information gain and heterogeneous costs (e.g., navigate time, and human attention). Extensive experiments in AI2-THOR demonstrate that ESearch-R1 significantly outperforms standard ReAct-based agents. It improves task success rates while reducing total operational costs by approximately 50\%, validating the effectiveness of GRPO in aligning MLLM agents with physical world constraints.